Establishment of Long-Term Tolerance to SRBC in Dogs by Recombinant Canine CTLA4-Ig
نویسندگان
چکیده
منابع مشابه
Long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and CD40 blockade.
BACKGROUND Prolonged survival of xenografted neonatal cardiomyocytes was achieved by blocking the CD28/B7 costimulatory pathway via CTLA4-Ig gene transfer. We examined the long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and transient CD40 blockade with anti-CD40L monoclonal antibody (MR1). METHODS AND RESULTS Neonatal cardiomyocytes derived...
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متن کاملA clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts.
BACKGROUND We determined whether a nontoxic CTLA4-Ig-based conditioning regimen effected mixed chimerism and donor-specific tolerance when heart and bone marrow were transplanted simultaneously. METHODS Fully mismatched rat strain combinations were used. Recipients received total-body irradiation (300 centigrays), bone marrow (10(8) cells), and cardiac transplants from the donor on day 0. Sub...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2009
ISSN: 0041-1337
DOI: 10.1097/tp.0b013e3181ae3285